Pair Name	All-trans retinoic acid, Decitabine
Disease Info	[ICD-11: 2A60.Z]	Acute myeloid leukemia		Investigative
Biological Phenomena	Induction-->ROS accumulation
Gene Regulation	Up-regulation	Cleavage	CASP3	hsa836
	Down-regulation	Expression	DUSP1	hsa1843
	Down-regulation	Expression	FTH1	hsa2495
	Down-regulation	Expression	GPX2	hsa2877
	Up-regulation	Expression	NFE2L2	hsa4780
	Down-regulation	Expression	NQO1	hsa1728
	Up-regulation	Cleavage	PARP1	hsa142
	Up-regulation	Activity	RARA	hsa5914
In Vitro Model	MDS	Childhood T acute lymphoblastic leukemia	Homo sapiens (Human)	CVCL_L807
	MOLM-13	Adult acute myeloid leukemia	Homo sapiens (Human)	CVCL_2119
In Vivo Model	1×10⁶ MOLM-13-Luciferase (MOLM-13-Luc) cells were injected via the tail veins to establish the cell line-derived xenograft (CDX) model.
Result	These results demonstrate that combining DAC and ATRA has potential for the clinical treatment of HR-MDS/AML and merits further exploration.